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After roughly 12 hours of fasting, your liver glycogen stores are depleted. Your body switches its primary fuel source from glucose to stored body fat. This metabolic switch is the core mechanism that makes intermittent fasting effective for weight management.
Extended fasting triggers autophagy — your body's cellular recycling system. Damaged proteins and organelles are broken down and reused. Research links autophagy to reduced inflammation, improved immune function, and potential longevity benefits.
Contrary to popular belief, short-term fasting increases metabolic rate by 3.6–14% due to elevated norepinephrine. Your body does not enter "starvation mode" during a 16–24 hour fast. Metabolism only slows with prolonged caloric restriction over weeks.
Everything you need to know about intermittent fasting, protocols, safety and what to expect — answered below.